Characterization of the CYP2C8 Active Site by Homology Modeling
نویسندگان
چکیده
منابع مشابه
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Human microsomal cytochrome P450s participate in drug metabolism and detoxification. Among them, CYP3A4 is the most important isoform for drug-drug interactions. To gain a better understanding of the active site, a homology model of CYP3A4 was constructed based on the crystallographic coordinates of mammalian CYP2C5. The putative active site is much larger than that of CYP2C5 and is divided int...
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ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2004
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.52.836